Our recent publication “Biomaterials and Oxygen Join Forces to Shape the Immune Response and Boost COVID-19 Vaccines” is featured as the Front Cover in the latest issue of Advanced Science.
In this work, in collaboration with the Griffiths lab at Boston University’s National Emerging Infectious Diseases Laboratories (NEIDL), we demonstrate that advanced biomaterials and oxygen can be leveraged to boost the effectiveness of SARS-CoV-2 vaccines.
Congratulations to Khushbu Bhatt and team (Loek Eggermont and Prof. Sidi A. Bencherif) on their recent publication in Engineering Technologies and Clinical Translation. This book chapter describes how polymeric scaffolds have been harnessed for immune cell priming and how they can be leveraged to prime immune cells and activate downstream antitumor responses. Finally, the challenges and future perspectives of immunomodulatory polymeric scaffolds are discussed for the successful clinical translation of current and emerging cancer immunotherapies.
Check it out here.
Congratulations to Tuerdimaimaiti Abudula, Thibault Colombani and team (Taofeek Alade, Prof. Sidi A Bencherif, and Prof. Adnan Memic) on their recent publication. They report an approach to engineer antibacterial, antioxidant, and injectable biomimetic cryogels by combining lignin with gelatin.
Check it out here.
One of our recent publications “Oxygen-Generating Cryogels Restore T-Cell Mediated Cytotoxicity in Hypoxic Tumors“ was featured as a Frontispiece in the latest issue of Advanced Functional Materials. Advanced Functional Materials reports breakthrough research in all aspects of materials science.
In this work, we report the design of injectable oxygen-generating cryogels as a new and minimally invasive strategy to boost antitumor immune responses.
Prof. Bencherif, 2021 Biomaterials Science Emerging Investigator, was recently interviewed by Laura Ghandhi, Development Editor at Royal Society of Chemistry, and is now featured on Biomaterials Science Blog. Check it out to learn more about our research and Prof. Bencherif’s perspective on Biomaterials Science and career-related advice.
Prof. Bencherif and team have recently published a research article in Biomaterials Science for their work on “Engineering a macroporous fibrin-based sequential interpenetrating polymer network for dermal tissue engineering”. This article reports on the synthesis and characterization of a new type of naturally derived and macroporous interpenetrating polymer network (IPN) for skin repair.
The lab was recently awarded a ~$2M R01 grant from NIH to tackle vaccine-associated hypoxia with advanced biomaterials to enhance cancer immunotherapy.
This project is focused on the development of biomaterial-based vaccines against prostate cancer. This work will integrate advanced injectable hydrogels, hypoxia-fighting nanoparticles, tumor-specific antigens, and immunostimulatory factors. We hypothesize that the proposed biomaterials can overcome hypoxia-driven immunosuppression in cancer vaccines and improve therapeutic efficacy.
The NIH fund will support this work in collaboration with Prof. Sitkovsky to further optimize and test this novel cancer vaccines in animal models, a critical step for translational research and moving on to the first stage of clinical testing in humans.
Check out the news story here for more information.
Joyce Shen, third-year biochemistry student, recently received an Honors Early Research Award from the Northeastern University Honors Program for her project, “Engineering polyester-coated nanoparticles for extended oxygen release”.
Congrats Joyce! More information can be found here.
In collaboration with the “laboratoire Biomécanique et Bioingénierie (BMBI)” at University of Technology of Compiègne/Sorbonne University, we report a new method for performing 3D cell cultures in microfluidic devices: a macroporous cryogel integrated biochip with tunable mechanical properties intended to mimic the stiffness of a healthy or pathological liver tissue.
This new cell culture device, combining a 3D microenvironment and perfusable cell culture, mimics the native liver microenvironment more closely by reconstructing its physiological stiffness. The feasibility study performed with HepG2/C3A showed viable and functional cells, enabling 3D tissue organization throughout the biochip. This device is a promising tool for potentially developing reliable in vitro liver microtissues for drug toxicity and efficacy studies, but it also may be a platform to better understand and dissect liver cell biology.
Check out our article here for more information.
One of our recent publications “Engineering a macroporous fibrin-based sequential interpenetrating polymer network for dermal tissue engineering” was featured on the front cover of the 2021 Biomaterials Science Emerging Investigators issue of Biomaterials Science. This article recently published in Biomaterials Science reports the synthesis and characterization of a new type of naturally derived and macroporous interpenetrating polymer network for skin repair.
This issue is part of the themed collection: Biomaterials Science Emerging Investigators 2021. Prof. Bencherif and other selected investigators were individually nominated by members of the journal Editorial and Advisory Boards, and previous Emerging Investigators, in recognition of their potential to influence future directions in the field of biomaterials.