Multimodal single-cell proteomics
The opportunities are beckoning. Which are likely to be most fruitful and impactful directions?
Category Archives: mass-spec proteomics
Label-free single-cell proteomics
Recently, Matthias Mann and colleagues published a preprint (doi: 10.1101/2020.12.22.423933v1) reporting a label-free mass-spectrometry method for single-cell proteomics. Many colleagues …
The cost of omics
Next generation DNA sequencing is ubiquitously integrated in modern biomedical research while mass-spectrometry proteomics remains less ubiquitous. In fact, mass-spectrometry …
When do you need single-cell analysis?
At HUPO, I have been repeatedly asked: “Why analyze single cells when you can identify more peptides in bulk samples?”
Direct causal mechanisms
Understanding biological systems: In search of direct causal mechanisms The advent of DNA-microarrays spurred a vigorous effort to reverse engineer …
Single-cell analysis
The success of imaging technologies The molecular and functional differences among the cells making our bodies have been appreciated for …
Single-cell proteomics
Ever since my lab posted the SCoPE-MS preprint, I have been repeatedly asked about the future potential and the cost …
Increasingly direct evidence
The results in our Cell report are particularly satisfying to me since they bring clarity to a puzzle that I …
