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~ Musings about practicing science & systems biology

Category Archives: mass-spec proteomics

Label-free single-cell proteomics

December 27, 2020

Recently, Matthias Mann and colleagues published a preprint (doi: 10.1101/2020.12.22.423933v1) reporting a label-free mass-spectrometry method for single-cell proteomics. Many colleagues …

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The cost of omics

May 25, 2020

Next generation DNA sequencing is ubiquitously integrated in modern biomedical research while mass-spectrometry proteomics remains less ubiquitous. In fact, mass-spectrometry …

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When do you need single-cell analysis?

August 14, 2019

At HUPO, I have been repeatedly asked: “Why analyze single cells when you can identify more peptides in bulk samples?”

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Direct causal mechanisms

April 7, 2019

Understanding biological systems: In search of direct causal mechanisms The advent of DNA-microarrays spurred a vigorous effort to reverse engineer …

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Single-cell analysis

November 14, 2018

The success of imaging technologies The molecular and functional differences among the cells making our bodies have been appreciated for …

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Single-cell proteomics

June 6, 2017

Ever since my lab posted the SCoPE-MS preprint, I have been repeatedly asked about the future potential and the cost …

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Increasingly direct evidence

October 24, 2015

The results in our Cell report are particularly satisfying to me since they bring clarity to a puzzle that I …

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