Multimodal single-cell proteomics
The opportunities are beckoning. Which are likely to be most fruitful and impactful directions?
Category Archives: Science
Label-free single-cell proteomics
Recently, Matthias Mann and colleagues published a preprint (doi: 10.1101/2020.12.22.423933v1) reporting a label-free mass-spectrometry method for single-cell proteomics. Many colleagues …
Promoting (your) research
“I am a scientist focused on conducting research, not on promoting it.” This thinking strongly resonated with me when I …
Bibliography for NIH proposals
NIH requires adding PMCID to references cited in proposals, and PMCID may be difficult to add because many reference libraries …
The cost of omics
Next generation DNA sequencing is ubiquitously integrated in modern biomedical research while mass-spectrometry proteomics remains less ubiquitous. In fact, mass-spectrometry …
Research success
We — the research community — can be much more successful if we invest more time and effort in what matters: Coming up with original new leads and helping each other grow as scientists and people. Happy and successful year to everybody!
When do you need single-cell analysis?
At HUPO, I have been repeatedly asked: “Why analyze single cells when you can identify more peptides in bulk samples?”
Direct causal mechanisms
Understanding biological systems: In search of direct causal mechanisms The advent of DNA-microarrays spurred a vigorous effort to reverse engineer …
Evaluating preprints
I am hugely enthusiastic for communicating research by preprints. So naturally, I am happy to see when the president and …
Single-cell analysis
The success of imaging technologies The molecular and functional differences among the cells making our bodies have been appreciated for …
