The Zhang Group

@ Northeastern University  

@ Northeastern:

  1. Wang, D.; Lu, X.; Jia, F.; Tan, X.; Cao, X.; Wai, F.; Zhang, K.* “Antisense gene regulation via co-assembled DNA- and poly(ethylene glycol)-based block copolymer amphiphiles”, submitted
  2. Antczak, N. M.; Packer, M. R.; Lu, X.; Zhang, K.; Beuning, P. J. “Human Y-family DNA polymerase kappa is more tolerant to changes in its active site loop than its ortholog E. coli DinB.”, Chemical Research in Toxicology. 2017, doi: 10.1021/acs.chemrestox.7b00175
  3. Wang, N.; Yu, X.; Zhang, K.*; Mirkin, C. A.*; Li, J.* “Upconversion nanoprobes for the ratiometric luminescent sensing of nitric oxide”, accepted in Journal of the American Chemical Society
  4. Cao, X.; Lu, X.; Wang, D.; Jia, F.; Tan, X.; Corley, M.; Chen, X.; Zhang, K.* “Modulating the cellular immune response of oligonucleotides by brush polymer-assisted compaction”, Small, 2017, doi: 10.1002/smll.201701432
  5. Jia F.; Lu, X.; Wang, D.; Cao, X.; Tan, X.; Zhang, K.* “Depth-profiling the nuclease stability and the gene silencing efficacy of brush-architectured poly(ethylene glycol)-DNA conjugates” Journal of the American Chemical Society, 2017, 139, 10605-10608
  6. Jia, F.; Lu, X.; Tan, X.; Wang, D.; Zhang, K.* “Effect of PEG architecture on the hybridization thermodynamics and protein accessibility of PEGylated oligonucleotides”, Angewandte Chemie International Edition, 2017, 56, 1239-1243
  7. Lu, X.; Jia, F.; Tan, X.; Wang, D.; Cao, X.; Zheng, J.; Zhang, K.* “Effective antisense gene regulation via non-cationic, polyethylene glycol brushes”, Journal of the American Chemical Society, 2016, 138, 9097-9100
  8. Tan, X.; Lu, X.; Jia, F.; Liu, X.; Logan, J. K.; Sun, Y.; Zhang, K.* “Blurring the role of oligonucleotides: Spherical nucleic acids as a drug delivery vehicle”, Journal of the American Chemical Society, 2016, 138, 10834-10837
  9. Lu, X.; Tran, T.-H.; Jia, F.; Tan, X.; Davis, S.; Amiji, M.; Zhang, K.* “Providing oligonucleotides with steric selectivity by brush polymer-assisted compaction”, Journal of the American Chemical Society, 2015, 137, 12466-12469
  10. Tan, Xu; Li, B. B.; Lu, X.; Jia, F.; Santori, C.; Menon, P.; Li, H.; Zhang, B.; Zhao, J. J.; Zhang, K.* “Light-triggered, self-immolative nucleic acid-drug nanostructures”, Journal of the American Chemical Society, 2015, 137, 6112-6115
  11. Chen, Y.; Zhang, K.; Wang, X.; Zhang, F.; Zhu, J.; Mays, J.; Wooley, K. L.; Pochan, D., “Multigeometry nanoparticles: Hybrid vesicle/cylinder nanoparticles constructed with block copolymer solution assembly and kinetic control”, Macromolecules, 2015, 48, 5621-5631
  12. Nevin, P.; Lu, X.; Zhang, K.; Engen, J. R.; Beuning, P. J. “Non-cognate DNA damage prevents formation of active conformation of Y-family polymerases DinB and Pol kappa”, FEBS, 2015, 29, 561.8
  13. Jia, F.; Lu, X.; Tan, X.; Zhang, K.* “Facile synthesis of nucleic acid-polymer amphiphiles and their self-assembly”, Chemical Communications 2015, 51, 7843-7846
  14. Lu, X.; Watts, E.; Jia, F.; Tan, X.; Zhang, K.* “Polycondensation of polymer brushes via DNA hybridization”, Journal of the American Chemical Society, 2014, 136, 10214-10217
  15. Zhang, K.*; Zhu, X.; Jia, F.; Auyeung, E.; Mirkin, C. A. “Temperature-activated nucleic acid nanostructures”, Journal of the American Chemical Society, 2013, 135, 14102-14015

 

Graduate and Postdoctoral Work:

  1. Zhu, J.; Zhang, S.; Zhang, K.; Wang, X.; Mays, J. W.; Wooley, K. L.; Pochan, D. J. “Disk-cylinder and disk-sphere nanoparticles from block copolymer blend solution construction”, Nat. Commun., 2013, doi:10.1038/ncomms3297
  2. Wang, Z.; Zhang, K.; Shen, Y.; Smith, J.; Bloch, S.; Achilefu, S.; Wooley, K. L.; Taylor, J.-S. A. “Imaging mRNA expression levels in living cells with PNA∙DNA binary FRET probes delivered by cationic shell-crosslinked nanoparticles”,  Org. Biomol. Chem., 2013, doi:10.1039/C3OB26923J
  3. Ibricevic, A.; Gunsten, S. P.; Zhang, K.; Shrestha, R.; Liu, Y.; Sun, J.; Welch, M. J.; Taylor, J.-S. A.; Wooley, K. L.; Brody, S. L. “PEGylation of cationic, shell-crosslinked knedel-like nanoparticles modulates inflammation and enhances cellular uptake in the lung”, Nanomedicine NBM, 2013, doi:10.1016/j.nano.2013.02.006
  4. Shen, Y.; Fang, H.; Zhang, K.; Shrestha, R.; Wooley, K. L.;  Taylor, J.-S. A. “Efficient protection and transfection of small interfering RNA by cationic shell-crosslinked knedel-like nanoparticles”, Nuc. Acid Ther., 2013, doi:10.1089/nat.2012.0390
  5. Wang, Z.; Zhang, K.; Wooley, K. L.; Taylor, J.-S. A. “Imaging mRNA expression in live cells via peptide nucleic acid (PNA) strand-displacement activated probes”, J. Nuc. Acids, 2012, doi:10.1155/2012/962652
  6. Zhang, K.; Hao, L.; Hurst, S. J.; Mirkin, C. A. “Antibody-linked spherical nucleic acids for cellular targeting”, J. Am. Chem. Soc., 2012, 134, 16488–16491
  7. Auyeung, E.; Cutler, J. I.; Macfarlane, R. J.; Jones, M. R.; Zhang, K.; Mirkin, C. A. “Synthetically programmable nanoparticle superlattices: The hollow three-dimensional spacer approach”, Nat. Nanotechnol., 2012, 7, 24-28 (Cover article; highlighted by MRS Bulletin)
  8. Zhang, K.; Zheng, D.; Hao, L.; Cutler, J. I.; Auyeung, E.; Mirkin, C. A. “ImmunoPods: Polymer shells with native antibody crosslinks”, Angew. Chem. Int. Ed., 2012, 5, 1169-1172 (Hot Paper)
  9. Pochan, D. J.; Zhu, J.; Zhang, K.; Wooley, K. L.; Miesch C.; Emrick, T. “Multicompartment and multigeometry nanoparticle assembly”, Soft Matter, 2011, 7, 2500-2506
  10. Cutler, J. I.; Zhang, K.; Zheng, D.; Auyeung, E.; Prigodich, A. E.; Mirkin, C. A. “Polyvalent nucleic acid nanostructures”, J. Am. Chem. Soc., 2011, 133, 9254-9257 (Equal first author; highlighted by C&EN and WTTW Chicago Tonight TV program)
  11. Zhang, K.; Cutler, J. I.; Zhang, J.; Zheng, D.; Auyeung, E.; Mirkin, C. A. “Nanopod formation through gold nanoparticle templated and catalyzed crosslinking of polymers bearing pendant propargyl ethers”, J. Am. Chem. Soc., 2010, 132, 15151-15153
  12. Zhang, J.; Langille, M. R.; Personick, M. L.; Zhang, K.; Li, S.; Mirkin, C. A. “Concave cubic gold nanocrystals with high-index facets”, J. Am. Chem. Soc.,  2010, 132, 14012-14014
  13. Sun, G.; Berezin, M.; Fan, J.; Lee, H.; Ma, J. Zhang, K.; Wooley, K. L.; Achilefu, S. “Bright fluorescent nanoparticles for developing potential optical imaging contrast agents”, Nanoscale, 2010, 2, 548-558
  14. Zhang, K.; Fang, H.; Wang, Z.; Li, Z.; Taylor, J.-S. A.; Wooley, K. L. “Structure-activity relationships of cationic shell-crosslinked knedel-like nanoparticles: Shell composition and transfection efficiency/cytotoxicity”, Biomaterials, 2010, 31, 1805-1813
  15. Ma, J.; Bartels, J. W.; Li, Z.; Zhang, K.; Cheng, C.; Wooley, K. L. “Synthesis and solution-state assembly or bulk state thiol-ene crosslinking of pyrrolidinone- and alkene-functionalized amphiphilic block  fluorocopolymers: from functional nanoparticles to anti-fouling coatings”, Aust. J. Chem., 2010, 63, 1159-1163
  16. Li, Z.; Ma, J.; Cheng, C.; Zhang, K.; Wooley, K. L. “Synthesis of  hetero-grafted  amphiphilic diblock molecular brushes and their self-assembly in aqueous medium”, Macromolecules, 2010, 43, 1182-1184
  17. Li, Y.; Hindi, K.; Watts, K. M.; Taylor, J. B.; Zhang, K.; Li, Z.; Hunstad, D. A. Cannon, C. L.; Youngs, W. J.; Wooley, K. L. “Shell crosslinked nanoparticles carrying silver antimicrobials as therapeutics”, Chem. Commun., 2010, 46, 121-123
  18. Zhang, K.; Fang, H.; Li, Z.; Ma, J.; Hohlbauch, S. V.; Taylor, J.-S. A.; Wooley, K. L. “Composite soft-matter nanoscale objects: nanocylinder-templated assembly of nanospheres”, Soft Matter, 2009, 5, 3585-3589 (Cover article)
  19. Zhang, K.; Fang, H.; Shen, G.; Taylor, J.-S. A.; Wooley, K. L. “Well-defined cationic shell crosslinked nanoparticles (cSCKs) for efficient delivery of DNA or PNA”, Proc. Am. Thorac. Soc., 2009, 6, 450-457 (Cover article)
  20. Fang, H.; Zhang, K.; Gang, S.; Wooley, K. L.; Taylor, J.-S. A. “Cationic shell-crosslinked knedel-like (cSCK) nanoparticles for highly efficient PNA delivery”, Mol. Pharm., 2009, 6, 615-626 (Equal first author)
  21. Li, Z.; Zhang, K.; Ma, J.; Cheng, C.; Wooley, K. L. “Facile synthesis of cylindrical molecular brushes by a sequential RAFT and ROM ‘grafting-through’ methodology”, J. Polym. Sci., Part A: Polym. Chem., 2009, 47, 5557-5563
  22. Zhang, K.; Fang, H.; Wang, Z.; Taylor, J.-S. A.; Wooley, K. L. “Cationic shell-crosslinked knedel-like nanoparticles (cSCKs) for highly efficient gene and oligonucleotide transfection of mammalian cells”, Biomaterials, 2009, 30, 968-977
  23. Sun, G.; Fang, H.; Cheng, C.; Lu, P.; Zhang, K.; Walker, A. V.; Taylor, J.-S. A.; Wooley, K. L. “Benzaldehyde-functionalized polymer vesicles”, ACS Nano, 2009, 3, 673-681
  24. Du, W.; Xu, Z.; Nystrom, A. M.; Zhang, K.; Leonard, J. R.; Wooley, K. L. “19F- and fluorescently labeled micelles as nanoscopic assemblies for chemotherapeutic delivery”, Bioconjugate Chem., 2008, 19, 2492-2498
  25. Zhang, K.; Rossin, R.; Hagooly, A.; Chen, Z.; Welch, M. J.; Wooley, K. L. “Folate-mediated cell uptake of shell-crosslinked spheres and cylinders”, J. Polym. Sci., Part A: Polym. Chem., 2008, 46, 7578-7583 (Cover article)
  26. Zhang, K.; Fang, H.; Chen, Z.; Taylor, J.-S. A.; Wooley, K. L. “Shape effects of nanoparticles conjugated with cell-penetrating peptides (HIV Tat PTD) on CHO cell uptake”, Bioconjugate Chem., 2008, 19, 1880-1887

List of publications

Mugar Hall, Rm 204

 

Department of Chemistry and Chemical Biology

 

Northeastern University

 

360 Huntington Avenue

 

Boston, MA 02115

 

​​Email: k.zhang (at) neu.edu Office: 617-373-4415