The Zhang Group

@ Northeastern University  

Peer-reviewed journal articles

 

At Northeastern:

45. Xiao, Y.; Li, H.; Zhang, B.; Cheng, Z.; Li, Y.; Tan, X.; Zhang, K.* “Self-immolative brush polymers based on poly(benzyl ether) backbones”, submitted

44. Li, H.; Zhang, B.; Lu, X.; Tan, X.; Jia, F.; Xiao, Y.; Cheng, Z.; Li, Y.; Mirkin, C. A.; Zhang, K.* “Molecular spherical nucleic acids”, under peer review at Nature Chemistry

43. Cressiot, B.; Greive, S. J.; Si, W.; Pascoa, T.; Mojtabavi, M.; Chechik, M.; Jenkins, H. T.; Lu, X.; Zhang, K.; Aksimentiev, A.; Antson, A. A.; Wanunu, M. “Porphyrin-assisted docking of a thermophage portal protein into lipid bilayers: nanopore engineering and characterization”; ACS Nano, 2017, DOI: 10.1021/acsnano.7b06980

42. Wang, D.; Lu, X.; Jia, F.; Tan, X.; Xiaoya, S.; Cao, X.; Wai, F.; Zhang, K.* “Precision tuning of DNA- and poly(ethylene glycol)-based nanoparticles via co-assembly for effective antisense gene regulation”, Chemistry of Materials, 2017, Just Accepted

41. Li, Y.; Sun, S.; Fan, L.; Hu, S.; Huang, Y.; K. Zhang.; Nie, Z.; Yao, S. “Peptide logic circuits based on chemoenzymatic ligation for programmable cell apoptosis”, Angewandte Chemie International Edition, 2017, DOI: 10.1002/anie.201708327

40. Antczak, N. M.; Packer, M. R.; Lu, X.; Zhang, K.; Beuning, P. J. “Human Y-family DNA polymerase kappa is more tolerant to changes in its active site loop than its ortholog E. coli DinB.”, Chemical Research in Toxicology, 2017, doi: 10.1021/acs.chemrestox.7b00175

39. Wang, N.; Yu, X.; Zhang, K.*; Mirkin, C. A.; Li, J. “Upconversion nanoprobes for the ratiometric luminescent sensing of nitric oxide”, Journal of the American Chemical Society, 2017, 139, 12354-12357

38. Cao, X.; Lu, X.; Wang, D.; Jia, F.; Tan, X.; Corley, M.; Chen, X.; Zhang, K.* “Modulating the cellular immune response of oligonucleotides by brush polymer-assisted compaction”, Small, 2017, doi: 10.1002/smll.201701432

37. Jia F.; Lu, X.; Wang, D.; Cao, X.; Tan, X.; Zhang, K.* “Depth-profiling the nuclease stability and the gene silencing efficacy of brush-architectured poly(ethylene glycol)-DNA conjugates” Journal of the American Chemical Society, 2017, 139, 10605-10608

36. Jia, F.; Lu, X.; Tan, X.; Wang, D.; Zhang, K.* “Effect of PEG architecture on the hybridization thermodynamics and protein accessibility of PEGylated oligonucleotides”, Angewandte Chemie International Edition, 2017, 56, 1239-1243

35. Lu, X.; Jia, F.; Tan, X.; Wang, D.; Cao, X.; Zheng, J.; Zhang, K.* “Effective antisense gene regulation via non-cationic, polyethylene glycol brushes”, Journal of the American Chemical Society, 2016, 138, 9097-9100

34. Tan, X.; Lu, X.; Jia, F.; Liu, X.; Logan, J. K.; Sun, Y.; Zhang, K.* “Blurring the role of oligonucleotides: Spherical nucleic acids as a drug delivery vehicle”, Journal of the American Chemical Society, 2016, 138, 10834-10837

33. Lu, X.; Tran, T.-H.; Jia, F.; Tan, X.; Davis, S.; Amiji, M.; Zhang, K.* “Providing oligonucleotides with steric selectivity by brush polymer-assisted compaction”, Journal of the American Chemical Society, 2015, 137, 12466-12469 (selected for JACS Young Investigator virtual issue)

32. Tan, Xu; Li, B. B.; Lu, X.; Jia, F.; Santori, C.; Menon, P.; Li, H.; Zhang, B.; Zhao, J. J.; Zhang, K.* “Light-triggered, self-immolative nucleic acid-drug nanostructures”, Journal of the American Chemical Society, 2015, 137, 6112-6115

31. Chen, Y.; Zhang, K.; Wang, X.; Zhang, F.; Zhu, J.; Mays, J.; Wooley, K. L.; Pochan, D., “Multigeometry nanoparticles: Hybrid vesicle/cylinder nanoparticles constructed with block copolymer solution assembly and kinetic control”, Macromolecules, 2015, 48, 5621-5631

30. Nevin, P.; Lu, X.; Zhang, K.; Engen, J. R.; Beuning, P. J. “Non-cognate DNA damage prevents formation of active conformation of Y-family polymerases DinB and Pol kappa”, FEBS, 2015, 29, 561.8

29. Jia, F.; Lu, X.; Tan, X.; Zhang, K.* “Facile synthesis of nucleic acid-polymer amphiphiles and their self-assembly”, Chemical Communications, 2015, 51, 7843-7846

28. Lu, X.; Watts, E.; Jia, F.; Tan, X.; Zhang, K.* “Polycondensation of polymer brushes via DNA hybridization”, Journal of the American Chemical Society, 2014, 136, 10214-10217

27. Zhang, K.*; Zhu, X.; Jia, F.; Auyeung, E.; Mirkin, C. A. “Temperature-activated nucleic acid nanostructures”, Journal of the American Chemical Society, 2013, 135, 14102-14015

 

Graduate and postdoctoral work:

26. Zhu, J.; Zhang, S.; Zhang, K.; Wang, X.; Mays, J. W.; Wooley, K. L.; Pochan, D. J. “Disk-cylinder and disk-sphere nanoparticles from block copolymer blend solution construction”, Nature Communications, 2013, doi:10.1038/ncomms3297

25. Wang, Z.; Zhang, K.; Shen, Y.; Smith, J.; Bloch, S.; Achilefu, S.; Wooley, K. L.; Taylor, J.-S. A. “Imaging mRNA expression levels in living cells with PNA∙DNA binary FRET probes delivered by cationic shell-crosslinked nanoparticles”, Organic and Biomolecular Chemistry, 2013, DOI:10.1039/C3OB26923J

24. Ibricevic, A.; Gunsten, S. P.; Zhang, K.; Shrestha, R.; Liu, Y.; Sun, J.; Welch, M. J.; Taylor, J.-S. A.; Wooley, K. L.; Brody, S. L. “PEGylation of cationic, shell-crosslinked knedel-like nanoparticles modulates inflammation and enhances cellular uptake in the lung”, Nanomedicine: Nanotechnology, Biology and Medicine, 2013, DOI:10.1016/j.nano.2013.02.006

23. Shen, Y.; Fang, H.; Zhang, K.; Shrestha, R.; Wooley, K. L.; Taylor, J.-S. A. “Efficient protection and transfection of small interfering RNA by cationic shell-crosslinked knedel-like nanoparticles”, Nucleic Acid Therapeutics, 2013, DOI:10.1089/nat.2012.0390

22. Wang, Z.; Zhang, K.; Wooley, K. L.; Taylor, J.-S. A. “Imaging mRNA expression in live cells via peptide nucleic acid (PNA) strand-displacement activated probes”, Journal of Nucleic Acids, 2012, DOI:10.1155/2012/962652

21. Zhang, K.; Hao, L.; Hurst, S. J.; Mirkin, C. A. “Antibody-linked spherical nucleic acids for cellular targeting”, Journal of the American Chemical Society, 2012, 134, 16488-16491

20. Auyeung, E.; Cutler, J. I.; Macfarlane, R. J.; Jones, M. R.; Zhang, K.; Mirkin, C. A. “Synthetically programmable nanoparticle superlattices: The hollow three-dimensional spacer approach”, Nature Nanotechnology, 2012, 7, 24-28 (Cover article; highlighted by MRS Bulletin)

19. Zhang, K.; Zheng, D.; Hao, L.; Cutler, J. I.; Auyeung, E.; Mirkin, C. A. “ImmunoPods: Polymer shells with native antibody crosslinks”, Angewandte Chemie International Edition, 2012, 5, 1169-1172 (Hot Paper)

18. Pochan, D. J.; Zhu, J.; Zhang, K.; Wooley, K. L.; Miesch C.; Emrick, T. “Multicompartment and multigeometry nanoparticle assembly”, Soft Matter, 2011, 7, 2500-2506

17. Cutler, J. I.; Zhang, K.; Zheng, D.; Auyeung, E.; Prigodich, A. E.; Mirkin, C. A. “Polyvalent nucleic acid nanostructures”, Journal of the American Chemical Society, 2011, 133, 9254-9257 (Equal first author; highlighted by C&EN and WTTW Chicago Tonight TV program)

16. Zhang, K.; Cutler, J. I.; Zhang, J.; Zheng, D.; Auyeung, E.; Mirkin, C. A. “Nanopod formation through gold nanoparticle templated and catalyzed crosslinking of polymers bearing pendant propargyl ethers”, Journal of the American Chemical Society, 2010, 132, 15151-15153

15. Zhang, J.; Langille, M. R.; Personick, M. L.; Zhang, K.; Li, S.; Mirkin, C. A. “Concave cubic gold nanocrystals with high-index facets”, Journal of the American Chemical Society, 2010, 132, 14012-14014

14. Sun, G.; Berezin, M.; Fan, J.; Lee, H.; Ma, J. Zhang, K.; Wooley, K. L.; Achilefu, S. “Bright fluorescent nanoparticles for developing potential optical imaging contrast agents”, Nanoscale, 2010, 2, 548-558

13. Zhang, K.; Fang, H.; Wang, Z.; Li, Z.; Taylor, J.-S. A.; Wooley, K. L. “Structure-activity relationships of cationic shell-crosslinked knedel-like nanoparticles: Shell composition and transfection efficiency/cytotoxicity”, Biomaterials, 2010, 31, 1805-1813

12. Ma, J.; Bartels, J. W.; Li, Z.; Zhang, K.; Cheng, C.; Wooley, K. L. “Synthesis and solution-state assembly or bulk state thiol-ene crosslinking of pyrrolidinone- and alkene-functionalized amphiphilic block fluorocopolymers: from functional nanoparticles to anti-fouling coatings”, Australian Journal of Chemistry, 2010, 63, 1159-1163

11. Li, Z.; Ma, J.; Cheng, C.; Zhang, K.; Wooley, K. L. “Synthesis of hetero-grafted  amphiphilic diblock molecular brushes and their self-assembly in aqueous medium”, Macromolecules, 2010, 43, 1182-1184

10. Li, Y.; Hindi, K.; Watts, K. M.; Taylor, J. B.; Zhang, K.; Li, Z.; Hunstad, D. A. Cannon, C. L.; Youngs, W. J.; Wooley, K. L. “Shell crosslinked nanoparticles carrying silver antimicrobials as therapeutics”, Chemical Communications, 2010, 46, 121-123

9. Zhang, K.; Fang, H.; Li, Z.; Ma, J.; Hohlbauch, S. V.; Taylor, J.-S. A.; Wooley, K. L. “Composite soft-matter nanoscale objects: nanocylinder-templated assembly of nanospheres”, Soft Matter, 2009, 5, 3585-3589 (Cover article)

8. Zhang, K.; Fang, H.; Shen, G.; Taylor, J.-S. A.; Wooley, K. L. “Well-defined cationic shell crosslinked nanoparticles (cSCKs) for efficient delivery of DNA or PNA”, Proceedings of the American Thoracic Society, 2009, 6, 450-457 (Cover article)

7. Fang, H.; Zhang, K.; Gang, S.; Wooley, K. L.; Taylor, J.-S. A. “Cationic shell-crosslinked knedel-like (cSCK) nanoparticles for highly efficient PNA delivery”, Molecular Pharmaceutics, 2009, 6, 615-626 (Equal first author)

6. Li, Z.; Zhang, K.; Ma, J.; Cheng, C.; Wooley, K. L. “Facile synthesis of cylindrical molecular brushes by a sequential RAFT and ROM ‘grafting-through’ methodology”, Journal of Polymer Science, Part A: Polymer Chemistry, 2009, 47, 5557-5563

5. Zhang, K.; Fang, H.; Wang, Z.; Taylor, J.-S. A.; Wooley, K. L. “Cationic shell-crosslinked knedel-like nanoparticles (cSCKs) for highly efficient gene and oligonucleotide transfection of mammalian cells”, Biomaterials, 2009, 30, 968-977

4. Sun, G.; Fang, H.; Cheng, C.; Lu, P.; Zhang, K.; Walker, A. V.; Taylor, J.-S. A.; Wooley, K. L. “Benzaldehyde-functionalized polymer vesicles”, ACS Nano, 2009, 3, 673-681

3. Du, W.; Xu, Z.; Nystrom, A. M.; Zhang, K.; Leonard, J. R.; Wooley, K. L. “19F- and fluorescently labeled micelles as nanoscopic assemblies for chemotherapeutic delivery”, Bioconjugate Chemistry, 2008, 19, 2492-2498

2. Zhang, K.; Rossin, R.; Hagooly, A.; Chen, Z.; Welch, M. J.; Wooley, K. L. “Folate-mediated cell uptake of shell-crosslinked spheres and cylinders”, Journal of Polymer Science, Part A: Polymer Chemistry, 2008, 46, 7578-7583 (Cover article)

1. Zhang, K.; Fang, H.; Chen, Z.; Taylor, J.-S. A.; Wooley, K. L. “Shape effects of nanoparticles conjugated with cell-penetrating peptides (HIV Tat PTD) on CHO cell uptake”, Bioconjugate Chemistry, 2008, 19, 1880-1887

 

Book chapters

2. Tan, X.; Zhang, K. “Photolabile self-immolative DNA-drug nanostructures”, Biomedical Nanotechnology: Methods and Protocols 2nd Edition, Edited by Hurst, S. J., Springer, New York, 2017, 209-221

1. Tan, X.; Burchfield, E.; Zhang, K. “Light-responsive drug delivery systems”, Stimuli-Responsive and Trigger Drug Delivery Systems, Edited by Amiji, M., RSC under review

 

 

List of publications

Mugar Hall, Rm 204

 

Department of Chemistry and Chemical Biology

 

Northeastern University

 

360 Huntington Avenue

 

Boston, MA 02115

 

​​Email: k.zhang (at) neu.edu Office: 617-373-4415