List of publications

The Zhang Group

@ Northeastern University  

2020

  • 2. Li, H.; Li, Y.; Xiao, Y.; Zhang, B.; Cheng, Z.; Shi, J.; Xiong, J.; Li, Z.; Zhang, K.* “Molecularly well-defined DNA-polymer miktoarm stars for enzyme-resistant nanoflares and carrier-free gene regulation”, Bioconjugate Chemistry, 2020, DOI: 10.1021/acs.bioconjchem.0c00017
  • Jia, F.; Song, J.; Kubiak, J.; Santos, P.; Sano, K.; Holten-Andersen, N.; Zhang, K.; Macfarlane, R. “Bottlebrush polymers as nanoscale building blocks for hydrogel synthesis”, submitted
  • 4. Qin, X.; Si, Y.; Wu, Z.; Zhang, K.; Li, J.; Yin, Y.  “Alkyne/Ruthenium(II) complex-based ratiometric SERS nanoprobe for in vitro and ex vivo tracking of carbon monoxide”, Analytical Chemistry, 2020, 92, 924
  • Shi, X.; Meng, H.; Chen, J.; Gao, Y.; Qu, L.; Zhang, K.; Zhang, X.; Li, Z. “DNA amplifier-functionalized metal-organic frameworks for multiplexed detection and imaging of intracellular mRNA”, ACS Sensors, 2020, DOI: 10.1021/acssensors.9b01759
  • Wu, Y.; Meng, H.; Chen, J.; Jiang, K.; Yang, R.; Li, Y.; Tang, J.; Zhang, K.; Qu, L.; Li, Z. “Accelerated DNAzyme-based fluorescent nanoprobe for highly sensitive microRNA imaging in live cells”, Chemical Communications, 2020, 56, 470
  • Yin, X.; Sun, Y.; Geng, X.; Li, J.; Yang, R.; Zhang, K.; Qu, L.; Li, Z. “Spatiotemporally monitoring cell viability through programmable mitochondrial membrane potential transformation by using fluorescent carbon dots”, Advanced Biosystems, 2020, DOI: doi.org/10.1002/adbi.201900261

2019

  • Xiao, Y.; Li, Y.; Zhang, B.; Li, H.; Cheng, Z.; Shi, J.; Xiong, J.; Bai, Y.; Zhang, K.* “Functionalizable, side chain-immolative poly(benzyl ether)s”, ACS Macro Letters, 2019, 8, 399
  • Jia, F.; Li, H.; Chen, R.; Zhang, K.* “Self-assembly of DNA-containing copolymers”, Bioconjugate Chemistry, 2019, DOI: 10.1021/acs.bioconjchem.9b00067
  • Wang, D.; Lin, J.; Jia, F.; Tan, X.; Wang, Y.; Sun, X.; Cao, X.; Che, F.; Lu, H.; Gao, X.; Shimkonis, J. C.; Nyoni, Z.; Lu, X.; Zhang, K.* “Bottlebrush-architectured poly(ethylene glycol) as an efficient vector for RNA interference in vivo”, Science Advances, 2019, DOI: 10.1126/sciadv.aav9322 (highlighted in Northeastern News and Science Trends)
  • Tan, X.; Lu, H.; Sun, Y.; Chen, X.; Wang, D.; Jia, F.; Zhang, K.* “Expanding the materials space of DNA via organic-phase ring-opening metathesis (co)polymerization”, Chem, accepted
  • Gudipati, S.; Zhang, K.; Rouge, J. L. “Towards self-transfecting nucleic acid nanostructures for gene regulation”, Trends in Biotechnology, 2019, DOI: 10.1016/j.tibtech.2019.01.008
  • Wang, N.; Song, L.; Xing, H.; Zhang, K.; Li, J. “Spherical nucleic acid-based two-photon nanoprobe for RNase H activity assay in living cells and tissues”, Nanoscale, 2019, DOI: 10.1039/C9NR00880B
  • Xie, Y.; Wang, N.; Li, Y.; Li, J.; Zhang, K.; Yu, R. “Cyclodextrin supramolecular inclusion-enhanced pyrene excimer switching for highly selective detection of RNase H”, Analytica Chimica Acta, 2019, DOI: j.aca.2019.08.059

2018

  • Jia, F.; Wang, D.; Lu, X.; Tan, X.; Wang, Y.; Lu, H.; Zhang, K.* “Improving the enzymatic stability and pharmacokinetics of oligonucleotides via DNA-backboned brush polymers”, Nano Letters, 2018, 18, 7378
  • Li, M.; Wang, C.; Di, Z.; Li, H.; Zhang, J.; Xue, W.; Zhao, M.; Zhang, K.; Zhao, Y.; Li, L. “Engineering multifunctional DNA hybrid nanospheres through coordination-driven self-assembly”, Angewandte Chemie International Edition, 2018, DOI: 10.1002/anie.201810735
  • Lu, X.; Zhang, K.* “PEGylation of therapeutic oligonucleotides – From linear to highly branched PEG architectures”, Nano Research, 2018, DOI: 10.1007/s12274-018-2131-8 (invited article for the 45 under 45 Young Investigator Award special issue)
  • Xiao, Y.; Li, H.; Zhang, B.; Cheng, Z.; Li, Y.; Tan, X.; Zhang, K.* “Modulating the depolymerization of self-immolative brush polymers with poly(benzyl ether) backbones”, Macromolecules, 2018, 51, 2899
  • Li, H.; Zhang, B.; Lu, X.; Tan, X.; Jia, F.; Xiao, Y.; Cheng, Z.; Li, Y.; Zhang, K.*; Mirkin, C. A. “Molecular spherical nucleic acids”, Proceedings of the National Academy of Sciences, USA, 2018, 115, 4340-4344
  • Tan, X.; Burchfield, E.; Zhang, K.* “Light-responsive drug delivery systems” in Stimuli-Responsive and Trigger Drug Delivery Systems, Edited by Singh, A. and Amiji, M., RSC Publishing, London, UK, 2018, 163-191

2017

  • Tan, X.; Zhang, K.* “Photolabile self-immolative DNA-drug nanostructures” in Biomedical Nanotechnology: Methods and Protocols 2nd Edition, Edited by Hurst, S. J., Springer, New York, USA, 2017, 209-221
  • Cressiot, B.; Greive, S. J.; Si, W.; Pascoa, T.; Mojtabavi, M.; Chechik, M.; Jenkins, H. T.; Lu, X.; Zhang, K.; Aksimentiev, A.; Antson, A. A.; Wanunu, M. “Porphyrin-assisted docking of a thermophage portal protein into lipid bilayers: nanopore engineering and characterization”; ACS Nano, 2017, 11, 11931-11945
  • Wang, D.; Lu, X.; Jia, F.; Tan, X.; Xiaoya, S.; Cao, X.; Wai, F.; Zhang, K.* “Precision tuning of DNA- and poly(ethylene glycol)-based nanoparticles via co-assembly for effective antisense gene regulation”, Chemistry of Materials, 2017, 29, 9882-9886
  • Li, Y.; Sun, S.; Fan, L.; Hu, S.; Huang, Y.; K. Zhang.; Nie, Z.; Yao, S. “Peptide logic circuits based on chemoenzymatic ligation for programmable cell apoptosis”, Angewandte Chemie International Edition, 2017, 56, 14888-14892
  • Antczak, N. M.; Packer, M. R.; Lu, X.; Zhang, K.; Beuning, P. J. “Human Y-family DNA polymerase kappa is more tolerant to changes in its active site loop than its ortholog E. coli DinB”, Chemical Research in Toxicology, 2017, doi: 10.1021/acs.chemrestox.7b00175
  • Wang, N.; Yu, X.; Zhang, K.*; Mirkin, C. A.; Li, J. “Upconversion nanoprobes for the ratiometric luminescent sensing of nitric oxide”, Journal of the American Chemical Society, 2017, 139, 12354-12357
  • Cao, X.; Lu, X.; Wang, D.; Jia, F.; Tan, X.; Corley, M.; Chen, X.; Zhang, K.* “Modulating the cellular immune response of oligonucleotides by brush polymer-assisted compaction”, Small, 2017, doi: 10.1002/smll.201701432
  • Jia F.; Lu, X.; Wang, D.; Cao, X.; Tan, X.; Zhang, K.* “Depth-profiling the nuclease stability and the gene silencing efficacy of brush-architectured poly(ethylene glycol)-DNA conjugates” Journal of the American Chemical Society, 2017, 139, 10605-10608
  • Jia, F.; Lu, X.; Tan, X.; Wang, D.; Zhang, K.* “Effect of PEG architecture on the hybridization thermodynamics and protein accessibility of PEGylated oligonucleotides”, Angewandte Chemie International Edition, 2017, 56, 1239-1243

2016

  • Lu, X.; Jia, F.; Tan, X.; Wang, D.; Cao, X.; Zheng, J.; Zhang, K.* “Effective antisense gene regulation via non-cationic, polyethylene glycol brushes”, Journal of the American Chemical Society, 2016, 138, 9097-9100
  • Tan, X.; Lu, X.; Jia, F.; Liu, X.; Logan, J. K.; Sun, Y.; Zhang, K.* “Blurring the role of oligonucleotides: Spherical nucleic acids as a drug delivery vehicle”, Journal of the American Chemical Society, 2016, 138, 10834-10837

2015

  • Lu, X.; Tran, T.-H.; Jia, F.; Tan, X.; Davis, S.; Amiji, M.; Zhang, K.* “Providing oligonucleotides with steric selectivity by brush polymer-assisted compaction”, Journal of the American Chemical Society, 2015, 137, 12466-12469 (selected for JACS Young Investigator virtual issue)
  • Tan, Xu; Li, B. B.; Lu, X.; Jia, F.; Santori, C.; Menon, P.; Li, H.; Zhang, B.; Zhao, J. J.; Zhang, K.* “Light-triggered, self-immolative nucleic acid-drug nanostructures”, Journal of the American Chemical Society, 2015, 137, 6112-6115
  • Chen, Y.; Zhang, K.; Wang, X.; Zhang, F.; Zhu, J.; Mays, J.; Wooley, K. L.; Pochan, D., “Multigeometry nanoparticles: Hybrid vesicle/cylinder nanoparticles constructed with block copolymer solution assembly and kinetic control”, Macromolecules, 2015, 48, 5621-5631
  • Nevin, P.; Lu, X.; Zhang, K.; Engen, J. R.; Beuning, P. J. “Non-cognate DNA damage prevents formation of active conformation of Y-family polymerases DinB and Pol kappa”, FEBS, 2015, 29, 561.8
  • Jia, F.; Lu, X.; Tan, X.; Zhang, K.* “Facile synthesis of nucleic acid-polymer amphiphiles and their self-assembly”, Chemical Communications, 2015, 51, 7843-7846

2014

  • Lu, X.; Watts, E.; Jia, F.; Tan, X.; Zhang, K.* “Polycondensation of polymer brushes via DNA hybridization”, Journal of the American Chemical Society, 2014, 136, 10214-10217

2013

  • Zhang, K.*; Zhu, X.; Jia, F.; Auyeung, E.; Mirkin, C. A. “Temperature-activated nucleic acid nanostructures”, Journal of the American Chemical Society, 2013, 135, 14102-14015
  • Zhu, J.; Zhang, S.; Zhang, K.; Wang, X.; Mays, J. W.; Wooley, K. L.; Pochan, D. J. “Disk-cylinder and disk-sphere nanoparticles from block copolymer blend solution construction”, Nature Communications, 2013, doi:10.1038/ncomms3297
  • Wang, Z.; Zhang, K.; Shen, Y.; Smith, J.; Bloch, S.; Achilefu, S.; Wooley, K. L.; Taylor, J.-S. A. “Imaging mRNA expression levels in living cells with PNA∙DNA binary FRET probes delivered by cationic shell-crosslinked nanoparticles”, Organic and Biomolecular Chemistry, 2013, doi:10.1039/C3OB26923J
  • Ibricevic, A.; Gunsten, S. P.; Zhang, K.; Shrestha, R.; Liu, Y.; Sun, J.; Welch, M. J.; Taylor, J.-S. A.; Wooley, K. L.; Brody, S. L. “PEGylation of cationic, shell-crosslinked knedel-like nanoparticles modulates inflammation and enhances cellular uptake in the lung”, Nanomedicine: Nanotechnology, Biology and Medicine, 2013, doi:10.1016/j.nano.2013.02.006
  • Shen, Y.; Fang, H.; Zhang, K.; Shrestha, R.; Wooley, K. L.; Taylor, J.-S. A. “Efficient protection and transfection of small interfering RNA by cationic shell-crosslinked knedel-like nanoparticles”, Nucleic Acid Therapeutics, 2013, doi:10.1089/nat.2012.0390

Prior to Northeastern

  • Wang, Z.; Zhang, K.; Wooley, K. L.; Taylor, J.-S. A. “Imaging mRNA expression in live cells via peptide nucleic acid (PNA) strand-displacement activated probes”, Journal of Nucleic Acids, 2012, doi:10.1155/2012/962652
  • Zhang, K.; Hao, L.; Hurst, S. J.; Mirkin, C. A. “Antibody-linked spherical nucleic acids for cellular targeting”, Journal of the American Chemical Society, 2012, 134, 16488-16491
  • Auyeung, E.; Cutler, J. I.; Macfarlane, R. J.; Jones, M. R.; Zhang, K.; Mirkin, C. A. “Synthetically programmable nanoparticle superlattices: The hollow three-dimensional spacer approach”, Nature Nanotechnology, 2012, 7, 24-28 (cover article; highlighted by MRS Bulletin)
  • Zhang, K.; Zheng, D.; Hao, L.; Cutler, J. I.; Auyeung, E.; Mirkin, C. A. “ImmunoPods: Polymer shells with native antibody crosslinks”, Angewandte Chemie International Edition, 2012, 5, 1169-1172 (Hot Paper)
  • Pochan, D. J.; Zhu, J.; Zhang, K.; Wooley, K. L.; Miesch C.; Emrick, T. “Multicompartment and multigeometry nanoparticle assembly”, Soft Matter, 2011, 7, 2500-2506
  • Cutler, J. I.; Zhang, K.; Zheng, D.; Auyeung, E.; Prigodich, A. E.; Mirkin, C. A. “Polyvalent nucleic acid nanostructures”, Journal of the American Chemical Society, 2011, 133, 9254-9257 (equal first author; highlighted by C&EN and WTTW Chicago Tonight TV program)
  • Zhang, K.; Cutler, J. I.; Zhang, J.; Zheng, D.; Auyeung, E.; Mirkin, C. A. “Nanopod formation through gold nanoparticle templated and catalyzed crosslinking of polymers bearing pendant propargyl ethers”, Journal of the American Chemical Society, 2010, 132, 15151-15153
  • Zhang, J.; Langille, M. R.; Personick, M. L.; Zhang, K.; Li, S.; Mirkin, C. A. “Concave cubic gold nanocrystals with high-index facets”, Journal of the American Chemical Society, 2010, 132, 14012-14014
  • Sun, G.; Berezin, M.; Fan, J.; Lee, H.; Ma, J. Zhang, K.; Wooley, K. L.; Achilefu, S. “Bright fluorescent nanoparticles for developing potential optical imaging contrast agents”, Nanoscale, 2010, 2, 548-558
  • Zhang, K.; Fang, H.; Wang, Z.; Li, Z.; Taylor, J.-S. A.; Wooley, K. L. “Structure-activity relationships of cationic shell-crosslinked knedel-like nanoparticles: Shell composition and transfection efficiency/cytotoxicity”, Biomaterials, 2010, 31, 1805-1813
  • Ma, J.; Bartels, J. W.; Li, Z.; Zhang, K.; Cheng, C.; Wooley, K. L. “Synthesis and solution-state assembly or bulk state thiol-ene crosslinking of pyrrolidinone- and alkene-functionalized amphiphilic block fluorocopolymers: from functional nanoparticles to anti-fouling coatings”, Australian Journal of Chemistry, 2010, 63, 1159-1163
  • Li, Z.; Ma, J.; Cheng, C.; Zhang, K.; Wooley, K. L. “Synthesis of hetero-grafted  amphiphilic diblock molecular brushes and their self-assembly in aqueous medium”, Macromolecules, 2010, 43, 1182-1184
  • Li, Y.; Hindi, K.; Watts, K. M.; Taylor, J. B.; Zhang, K.; Li, Z.; Hunstad, D. A. Cannon, C. L.; Youngs, W. J.; Wooley, K. L. “Shell crosslinked nanoparticles carrying silver antimicrobials as therapeutics”, Chemical Communications, 2010, 46, 121-123
  • Zhang, K.; Fang, H.; Li, Z.; Ma, J.; Hohlbauch, S. V.; Taylor, J.-S. A.; Wooley, K. L. “Composite soft-matter nanoscale objects: nanocylinder-templated assembly of nanospheres”, Soft Matter, 2009, 5, 3585-3589 (cover article)
  • Zhang, K.; Fang, H.; Shen, G.; Taylor, J.-S. A.; Wooley, K. L. “Well-defined cationic shell crosslinked nanoparticles (cSCKs) for efficient delivery of DNA or PNA”, Proceedings of the American Thoracic Society, 2009, 6, 450-457 (cover article)
  • Fang, H.; Zhang, K.; Gang, S.; Wooley, K. L.; Taylor, J.-S. A. “Cationic shell-crosslinked knedel-like (cSCK) nanoparticles for highly efficient PNA delivery”, Molecular Pharmaceutics, 2009, 6, 615-626 (equal first author)
  • Li, Z.; Zhang, K.; Ma, J.; Cheng, C.; Wooley, K. L. “Facile synthesis of cylindrical molecular brushes by a sequential RAFT and ROM ‘grafting-through’ methodology”, Journal of Polymer Science, Part A: Polymer Chemistry, 2009, 47, 5557-5563
  • Zhang, K.; Fang, H.; Wang, Z.; Taylor, J.-S. A.; Wooley, K. L. “Cationic shell-crosslinked knedel-like nanoparticles (cSCKs) for highly efficient gene and oligonucleotide transfection of mammalian cells”, Biomaterials, 2009, 30, 968-977
  • Sun, G.; Fang, H.; Cheng, C.; Lu, P.; Zhang, K.; Walker, A. V.; Taylor, J.-S. A.; Wooley, K. L. “Benzaldehyde-functionalized polymer vesicles”, ACS Nano, 2009, 3, 673-681
  • Du, W.; Xu, Z.; Nystrom, A. M.; Zhang, K.; Leonard, J. R.; Wooley, K. L. “19F- and fluorescently labeled micelles as nanoscopic assemblies for chemotherapeutic delivery”, Bioconjugate Chemistry, 2008, 19, 2492-2498
  • Zhang, K.; Rossin, R.; Hagooly, A.; Chen, Z.; Welch, M. J.; Wooley, K. L. “Folate-mediated cell uptake of shell-crosslinked spheres and cylinders”, Journal of Polymer Science, Part A: Polymer Chemistry, 2008, 46, 7578-7583 (cover article)
  • Zhang, K.; Fang, H.; Chen, Z.; Taylor, J.-S. A.; Wooley, K. L. “Shape effects of nanoparticles conjugated with cell-penetrating peptides (HIV Tat PTD) on CHO cell uptake”, Bioconjugate Chemistry, 2008, 19, 1880-1887

Department of Chemistry and Chemical Biology

 

Northeastern University

 

360 Huntington Avenue

 

Boston, MA 02115

 

​​Email: k.zhang (at) neu.edu Office: 617-373-7089

Last Updated: Feb 2020