The Zhang Group

@ Northeastern University  

MACROMOLECULAR CHEMISTRY EXPLORING the bio-materials interface

Research Synposis

Advances in polymer chemistry have enabled the synthesis of polymers that are well-defined in architecture, composition, and polydispersity. Our group focuses broadly on developing synthetic methodologies for functional polymers and on their integration into nanostructured materials and/or bioconjugates, with the ultimate goal of opening new possibilities in drug delivery, immunotherapy, and gene regulation.

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POSITIONS AVAILABLE

graduate students and postdoc fellows

We are always looking for talented graduate students and postdoctoral fellows. Right now we are particularly interested in acquiring talent in cell biology and pharmacological work).

Lab renovation log

CHECK out our lab renovation pictures

It took a while to get there, but the result is worth the wait!

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RECENT publications

Dec 2016

Effect of PEG architecture on the hybridization thermodynamics and protein accessibility of PEGylated oligonucleotides

Fei Jia, et al

Angew. Chem. Int. Ed., 2017, 56, 1239

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Jul 2017

Depth-profiling the nuclease stability and the gene silencing efficacy of brush-architectured poly(ethylene glycol)-DNA conjugates

Fei Jia, et al

J. Am. Chem. Soc., 2017, 139, 10605

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Jun 2017

Modulating the cellular immune response of oligonucleotides by brush polymer-assisted compaction

Xueyan Cao, Xueguang Lu, et al

Small, 2017,  doi: 10.1002/smll.201701432

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GrouP News

(Sep, 2107) Prof. Zhang received an R01 grant from the National Institute of General Medical Sciences of the National Institutes of Health

(Aug, 2017) Our DFCI-NEU Cancer Grant is renewed for a 2nd year of support!

(Jun, 2017) Fei defended his thesis, “Improving the biopharmaceutical properties of oligonucleotides and oligopeptides through polymer conjugation and architecture design”, with flying colors! He is to join Prof. Robert MacFarlane’s group at MIT. Congratulations Fei!

(Jul, 2017) Fei is on a roll too! His third paper, “Depth-profiling the nuclease stability and the gene silencing efficacy of brush-architectured poly(ethylene glycol)-DNA conjugates”, is accepted for publication in JACS! Congrats Fei!

(Jun, 2017) The manuscript by Xueyan and Xueguang, “Modulating the cellular immune response of oligonucleotides by brush polymer-assisted compaction”, is accepted for publication in Small! We are so glad that Xueyan get to bring home the fruit of her short stay in Boston as a visiting scholar.

(Jun, 2017) Prof. Ke Zhang is promoted to associate professor.

(Apr, 2017) Xuyu won a Best Oral Presentation Award at the Annual Northeast Student Chemistry Research Conference! Good job Xuyu!

(Apr, 2017) Xueguang successfully defended his PhD thesis, “Investigation of brush polymers for nucleic acid delivery and self-assembly”. He is to join Prof. Robert Langer’s group at MIT. Such a bitter-sweet day. Sweet mostly.

(Apr, 2017) Hao Lu officially joins our group as a first-year PhD student! Welcome Hao!

(Feb, 2017) Prof. Lanxia Liu from the Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College has joined us for a one-year stay as a visiting scholar. Welcome Lanxia!

(Dec, 2016) I’m thrilled that Xueguang won the coveted Provost Office’s Dissertation Completion Fellowship! The fellowship is highly-competitive and is reserved for students of the highest caliber. We are proud of you, Xueguang!

(Dec, 2016) Fei’s excellent in-depth study on pacDNA thermodynamics is accepted for publication in Angewandte Chemie International Edition! The paper is titled “Effect of PEG architecture on the hybridization thermodynamics and protein accessibility of PEGylated oligonucleotides”. Fantastic job, Fei!

(Nov, 2016) Xueguang is selected to present in the 2017 Excellence in Graduate Polymer Research Symposium at the ACS meeting. Selection to this symposium is a distinct honor and recognition in the polymer community.

(Aug, 2016) We really appreciate the continued support from the DFCI-NEU Cancer Research program with Prof. Jean Zhao at DFCI!

(Aug, 2016) Xuyu’s paper, “Blurring the role of oligonucleotides: spherical nucleic acids as a drug delivery vehicle”, received overwhelmingly positive reviews and is published as-is in JACS without any revision. Just. Amazing.

(Jul, 2016) Xueguang is on a roll! His third JACS paper, “Effective antisense gene regulation via non-cationic, polyethylene glycol brushes” is just accepted!

(Apr, 2016) Xueguang won the College of Science Dean’s Award for Graduate Student Excellence in Research. Only one student from five departments gets it per year. Congratulations Xueguang!

(Mar, 2016) Prof. Xueyan Cao from Donghua University in Shanghai joined us for a one-year stay as a China Scholarship Council-supported visiting scholar! Welcome Xueyan!

(Feb, 2016) Dr. Dali Wang from Shanghai Jiaotong University joins us as a postdoctoral fellow. Welcome Dali! We are glad to have you.

(Sep, 2015) Xueguang's second JACS paper, titled "Providing oligonucleotides with steric selectivity by brush-polymer-assisted compaction", has been published! Excellent work Xueguang!

 

 

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