Postdoctoral Research Associate
My overarching focus has been to understand the molecular mechanisms or antibiotic resistance and tolerance in bacterial pathogens. My previous research has focused on the interface between antibiotic resistance and virulence in the problematic human pathogen Staphylococcus aureus. I have used ‘-omics’ based approaches (genomics, transcriptomics, proteomics) and targeted mutagenesis to describe novel mechanisms of antibiotic resistance, and a range of murine infection models to understand the virulence and persistence of multidrug resistant S. aureus.
At the Antimicrobial Discovery Center, I am currently focused on identifying the genetic correlates of persister cell formation in S. aureus and the opportunistic human pathogen Pseudomonas aeruginosa.
Cameron DR, Jiang JH, Kostoulias X, Foxwell D, Peleg AY. Vancomycin susceptibility in methicillin-resistant Staphylococcus aureus is mediated by YycHI activation of the WalRK essential two-component regulatory system. Scientific Reports 2016;6:30823
Cameron DR, Mortin LI, Rubio A, Mylonakis E, Moellering RC, Eliopoulos GM, Peleg AY. Impact of Daptomycin Resistance on Staphylococcus aureus Virulence. Virulence 2015;6(2):127-31.
Cameron DR, Ward D, Kostoulias X, Howden BP, Moellering RC, Eliopoulos GM, Peleg AY. Serine/threonine phosphatase Stp1 contributes to reduced susceptibility to vancomycin and virulence in Staphylococcus aureus. Journal of Infectious Diseases 2012;205(11):1677-87.
Cameron DR, Howden BP, Peleg AY. The interface between antibiotic resistance and virulence in Staphylococcus aureus and its impact upon clinical outcomes. Clinical Infectious Diseases 2011;53(6):576-82