Our laboratory studies persister cells responsible for tolerance to antibiotics, uncultured bacteria of the environment and the microbiome, and works on drug discovery.

 

Kim Lewis, Ph.D.

Kim   

 

Contact

Room 306C Mugar Life Sciences Building
Northeastern University
360 Huntington Ave
Boston, MA 02115

Email: k.lewis@neu.edu
Tel: 617.373.8238

 

Selected Publications

Strandwitz P, Kim KH, Terekhova D, Liu JK, Sharma A, Levering J, McDonald D, Dietrich D, Ramadhar TR, Lekbua A, Mroue N, Liston C, Stewart EJ, Dubin MJ, Zengler K, Knight R, Gilbert JA, Clardy J, Lewis K. (2018). GABA-modulating bacteria of the human gut microbiota. Nat Microbiol. [Epub ahead of print]

Wu X, Sharma B, Niles S, O’Connor K, Schilling R, Matluck N, D’Onofrio A, Hu LT, Lewis K. (2018). Identifying Vancomycin as an effective antibiotic for killing Borrelia Burgdorferi. Antimicrob. Agents Chemother. e01201-18.

Fenn K*, Strandwitz P*, Stewart EJ, Dimise E, Rubin S, Gurubacharya S, Clardy J, Lewis K. (2017). Quinones are growth factors for the human gut microbiota. Microbiome. 5(1):161.

Shan Y*, Brown Gandt A*, Rowe SE, Deisinger JP, Conlon BP, Lewis K. (2017). ATP dependent persister formation in Escherichia coli. mBio 8:e02267-16.

Conlon B, Rowe SE, Brown Gandt A, Nuxoll A, Donegan N, Zalis E, Clair G, Adkins J, Cheung A, Lewis K. (2016). Persister formation in Staphylococcus aureus is associated with ATP depletion. Nature Microbiol. 1:16051.

Schumacher, M., Balani, P., Min, J., Chinnam, N., Hansen, S., Vulić, M., Lewis, K.*, Brennan, R.* (2015) HipAB-promoter structures reveal basis of heritable multidrug tolerance. Nature. 524:59-64. (*co-corresponding authors)

Ling, L., Schneider, T., Peoples, A., Spoering, A., Engels, I., Conlon, B., Mueller, A., Schäberle, T., Hughes, D., Epstein, S., Jones, M., Lazarides, L., Steadman, V., Cohen, D., Felix C., Fetterman, K., Millett, W., Nitti, A.,Zullo, A., Chen, C., and Lewis, K. (2015) A novel antibiotic kills pathogens without detectable resistance. Nature. 517:455-459.

Gavrish, E., C. S. Sit, S. Cao, O. Kandror, A. Spoering, A. Peoples, L. Ling, A. Fetterman, D. Hughes, A. Bissell, H. Torrey, T. Akopian, A. Mueller, S. Epstein, A. Goldberg, J. Clardy and K. Lewis. (2014) Lassomycin, a ribosomally synthesized cyclic peptide, kills Mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2. Chem Biol. 21: 509-518.

Conlon, B., Nakayasu, E., Fleck, L., LaFleur, M., Isabella, V., Coleman, K., Leonard, S., Smith, R., Adkins, J. and Lewis, K. (2013) Activated ClpP kills persisters and eradicates a chronic biofilm infection. Nature. 503(7476):365-370.

Keren, I., Wu, Y., Innocencio, J., Mulcahy, L., and Lewis, K. (2013) Killing by bactericidal antibiotics does not depend on reactive oxygen species. Science. 339:1213-1216.

Dörr, T., Vulić, M., Lewis, K. (2010) Ciprofloxacin Causes Persister Formation by Inducing the TisB toxin in Escherichia coli. PLoS Biology. e1000317.

D’Onofrio, A., Crawford, J., Stewart, E., Witt, K., Gavrish, E., Epstein, S., Clardy, J., Lewis, K. (2010) Siderophores from Neighboring Organisms Promote the Growth of Uncultured Bacteria. Chemistry & Biology. 17(3):254-264.